Tools for microbiome research

In 1907, Metchnikoff theorized aging as caused by rogue bacterial colonization of the colon. The theory fell out of favor because subsequent researchers could not isolate a toxin which “must have been” involved.

In 2010, Gerontologist Ro Blake suspected the cause of aging was actually a competition for resource. Blake observed that certain amino acids were being broken-down for energy by epithelial cells in the small intestine. This was occurring at the same time the identical amino acids were being removed from collagen to provide for immune and peptide production.

Blake imagined this as part of a bodily process to deny nutrients to downstream bacteria.

As a pharmacist, Blake developed an amino acid formulation that prevents break-down of specific amino acids while also preventing absorption by bacteria.

What needs further study?

In the 2012 clinical trials (and at highest doses) herpes outbreaks were noticed among those with known existing herpes infection.  These outbreaks would not be repeated, subsequently.  As the outbreak mechanism of herpes virus is known, it was assumed that at higher doses this compound may have cleared the virus.  Could what appeared to the virus to be breakdown of collagen actually have it walking it into an immune system that was not preoccupied with a preexisting infection?

Alzheimer’s disease (AD) is a condition involving plaque formation in the human brain, usually but not always, occurring in much older individuals.   Plaque formation has recently been identified as a secondary immune function to immobilize pathogens.  As the standard immune system generally cannot get past the blood brain barrier plaque may occur in response to a long-term herpes infection.  Older individuals, especially, do not have much collagen to spare. Without the break-down of collagen “all clear signal,” herpes may remain within the brain.

Older individuals have a much more difficult time in dealing with COVID-19.  Could a nutritional supplement prove useful in prevention and recovery from COVID-19?