New Findings in Evolution are behind Microbiome research
All mammals have around 25,000 genes, yet humans are by far the most sophisticated. Our similar number of genes can code advanced processes because humans utilize thousands of bacterial species to produce the precursors and chemical intermediates of human protein. Human genes actually appear to begin few processes from absolute scratch. Bacteria provide the starting materials especially for uniquely human neurotransmitters. However, there may be a downside. In 1907, Metchnikoff theorized that bacteria colonization of the colon was the cause of aging.
Decline in physical protein structure and increasing loss of function define aging. Diseases of aging are easily explainable by lack of collagen, peptides and hormones. These proteins are only formed with the complete supply of all twenty amino acids. Lack of a single amino acid is enough to prevent RNA from producing a needed protein. The borrowing of a specific missing amino acid from structure then becomes the first visible sign of aging.
The new theory is that explosive growth of gut bacteria is a trigger of normal aging. Accordingly, exponential bacterial growth would utilize all available amino acid nutrition in the colon. The accepted orthodoxy insists that bacteria produce their own supply of amino acids. The new theory supposes that rogue bacteria evolve to utilize under utilized amino acids. (In fact, this led to further studies, eventually proving bacterial evolution.)
It is a critical function that lymph circulates amino acids from the intestine to the lymph nodes. As muscle movement alone circulates lymph, lack of exercise causes stagnation and exposes extra nutrition to rogue bacteria. Fat and carbs are generally always well absorbed in humans. This would cause many to gain weight while undergoing a protein starvation that doesn’t appear to be starvation. (Many factors seem to come together to amplify the decline of age.)
The Metchnikoff theory was abandoned because researchers of the day could not isolate the ”toxin” they believed responsible. Still today there is unwavering faith in existing orthodoxy. When this research began, the specific amino acid cited above was considered non-essential. It is only lately being accepted as conditionally essential in the elderly. Obviously it is essential.
Applications for US patent on potential nutritional supplements were filed in 2012-13 ©